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Tao Wang, Robert C. Elston  The American Journal of Human Genetics 

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Presentation on theme: "Tao Wang, Robert C. Elston  The American Journal of Human Genetics "— Presentation transcript:

1 Improved Power by Use of a Weighted Score Test for Linkage Disequilibrium Mapping 
Tao Wang, Robert C. Elston  The American Journal of Human Genetics  Volume 80, Issue 2, Pages (February 2007) DOI: /511312 Copyright © 2006 The American Society of Human Genetics Terms and Conditions

2 Figure 1. Compression of the genotypic differences among 100 controls and 100 cases by FT. Subjects 1–100 are the controls, and subjects 101–200 are the cases. A, Original genotype values. B, Recoded genotype values. C, FT components. The American Journal of Human Genetics  , DOI: ( /511312) Copyright © 2006 The American Society of Human Genetics Terms and Conditions

3 Figure 2. LD-pattern color plot for simulations generated with ρ sampled from a uniform distribution between 0.3 and 0.7. The scale from lower values (yellow) to higher values (red) corresponds to the increase in the absolute values of correlation. The American Journal of Human Genetics  , DOI: ( /511312) Copyright © 2006 The American Society of Human Genetics Terms and Conditions

4 Figure 3. Type I error rates of four tests with m=4 (A) and m=10 (B) at the 5% level under different ρ values in simulations. The solid horizontal line is the nominal 0.05 level. Analysis is based on 100 cases and 100 controls, with ρ taking on the values 0.1, 0.2, 0.3,…, 0.8. The statistics TB, TP, TH, and Tw are denoted B, P, H, and W, respectively. The American Journal of Human Genetics  , DOI: ( /511312) Copyright © 2006 The American Society of Human Genetics Terms and Conditions

5 Figure 4. Empirical powers of different approaches with m=4 at the 5% level for a multiplicative model. The disease-allele frequency is given by p (0.2, 0.3, or 0.4). A, ρ=0.4. B, ρ=0.8|i-j|. C, ρ is sampled from a uniform distribution between 0.3 and 0.7. The statistics TB, TP, TH, and Tw are denoted B, P, H, and W, respectively. The American Journal of Human Genetics  , DOI: ( /511312) Copyright © 2006 The American Society of Human Genetics Terms and Conditions

6 Figure 5. Empirical powers of different approaches with m=10 at the 5% level for a multiplicative model. The disease-allele frequency is given by p (0.2, 0.3, or 0.4). A, ρ=0.4. B, ρ=0.8|i-j|. C, ρ is sampled from a uniform distribution between 0.3 and 0.7. The statistics TB, TP, TH, and Tw are denoted B, P, H, and W, respectively. The American Journal of Human Genetics  , DOI: ( /511312) Copyright © 2006 The American Society of Human Genetics Terms and Conditions

7 Figure 6. Empirical powers of different approaches for a multiplicative model based on the real LD pattern of CHI3L2. The statistics TB, TP, TH, and Tw are denoted B, P, H, and W, respectively. The American Journal of Human Genetics  , DOI: ( /511312) Copyright © 2006 The American Society of Human Genetics Terms and Conditions


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