1. The CB1 receptor is one of the most abundant neurotransmitter receptors in the brain

2. When cannabis is smoked the active principle of this drug, THC, reaches the brain

3. THC then binds to the CB1 receptor

4. THC then binds to the CB1 receptor

5. Cannabis Intoxication
THC over-activates the CB1 inducing cannabis intoxication
Cannabis
Intoxication

6. Cannabis Intoxication
Higher doses of THC, above those found in cannabis smokers, increase pregnenolone levels in the brain
THC over-activates the CB1 inducing cannabis intoxication
Cannabis
Intoxication

7. Cannabis Intoxication
Pregnenolone then binds to a specific site on the CB1
Cannabis
Intoxication

8. Pregnenolone decreases the effects of THC on the CB1

9. Cannabis intoxication is then reduced
Cannabis Effects

10. Reduced Cannabis Effects
Pregnenolone is a natural defense that can protect the brain from cannabis
Reduced
Cannabis Effects