1. Helicobacter pylori and Gastric Cancer: A New Paradigm For Inflammation-Associated Epithelial Cancers 
JeanMarie Houghton, Timothy C. Wang 
Gastroenterology 
Volume 128, Issue 6, Pages (May 2005)
DOI: /j.gastro
Copyright © 2005 American Gastroenterological Association Terms and Conditions

2. Figure 1
Multistep model for the progression of gastric cancer (adapted from Fox JG, Wang TC. N Engl J Med 2001;345:829–832).
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2005 American Gastroenterological Association Terms and Conditions

3. Figure 2
Engraftment of bone marrow-derived cells in the gastric mucosa: effects of time and infection. C57BL/6 mice were myloablated and underwent transplantation with marrow from wild-type C57BL/6 or ROSA-26 mice carrying the β-galactosidase gene. After recovery, mice were infected with Helicobacter felis or vehicle control. Engrafting cells were detected using x-gal reagent, which produces a blue cytoplasm in cells expressing the β-galactosidase enzyme. (A) C57BL/6 mice that underwent transplantation with C57BL/6 marrow, infected with H felis for 30 weeks, do not show reactivity with x-gal reagent (blue). Larger area from the same mouse shown in F. (B) C57BL/6 mice that underwent transplantation with ROSA-26 marrow and sham infected or, in C, infected with H felis for 4 weeks demonstrate marrow-derived (blue) inflammatory cells. We did not demonstrate any gastric epithelial glands, which were bone marrow derived. (D) ROSA transplantation mice infected for 20 weeks had few marrow-derived glands (blue, arrow). (E) By 12–18 months of chronic infection, large numbers of glands were completely replaced by cells that were marrow derived (blue). (G) Low-power view of the area. (Figure provided courtesy of Dr JeanMarie Houghton.)
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2005 American Gastroenterological Association Terms and Conditions

4. Figure 3
The new model of epithelial cancer. (Figure provided courtesy of Dr JeanMarie Houghton.)
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2005 American Gastroenterological Association Terms and Conditions