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Emily M. DeBoer, MD, David R. Spielberg, MD, MHSc, Alan S. Brody, MD 

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Presentation on theme: "Emily M. DeBoer, MD, David R. Spielberg, MD, MHSc, Alan S. Brody, MD "— Presentation transcript:

1 Clinical potential for imaging in patients with asthma and other lung disorders 
Emily M. DeBoer, MD, David R. Spielberg, MD, MHSc, Alan S. Brody, MD  Journal of Allergy and Clinical Immunology  Volume 139, Issue 1, Pages (January 2017) DOI: /j.jaci Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Quantitative CT in a patient with severe asthma shows airway narrowing (B) and increased low-attenuation areas, a marker of hyperinflation (D), when compared with a healthy subject (A and C).39 Journal of Allergy and Clinical Immunology  , 21-28DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 HP gas MRI images can reveal lung ventilation changes before and after medical or surgical interventions without concern for repeated radiation exposures. Shown here are images obtained from a patient at baseline and 3 months after undergoing bronchial thermoplasty. Reproduced with permission of the Radiological Society of North America, from Thomen et al.71 Journal of Allergy and Clinical Immunology  , 21-28DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 A, Chest EIT data are gathered by measuring the voltage across electrodes placed around the circumference of the chest after applying a defined current. B, Conductivity, a measure of impedance, is calculated for pixels in the cross-sectional plane of the electrodes, and an estimate of continuous ventilation and perfusion in an axial plane of a patient's chest is produced. Journal of Allergy and Clinical Immunology  , 21-28DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Optical coherence tomography combined with flexible bronchoscopy can visualize microscopic airway characteristics, including epithelium (EPI), basement membrane (BM), and smooth muscle (SM). Reproduced with permission of the European Respiratory Society from Kirby et al.96 Journal of Allergy and Clinical Immunology  , 21-28DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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