1. Stereoimage of three independent docking simulations of the interaction between clopidogrel acyl 1-β-d-glucuronide and the active site of CYP2C8.
Stereoimage of three independent docking simulations of the interaction between clopidogrel acyl 1-β-d-glucuronide and the active site of CYP2C8. Clopidogrel acyl-β-d-glucuronide is rendered with gray sticks depicting carbon atoms. The distance between clopidogrel acyl-β-d-glucuronide thiophene ring carbon and heme iron is indicated by a green line. Other atoms of the clopidogrel acyl-β-d-glucuronide molecule are colored red for oxygen, blue for nitrogen, yellow for sulfur, and green for chlorine.
Janne T. Backman et al. Pharmacol Rev 2016;68:
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