1. Representative families of force responses to various amplitudes of quick stretch and quick release.
Representative families of force responses to various amplitudes of quick stretch and quick release. Families of force responses, F(t), to four amplitudes of quick stretch and four amplitudes of quick release in two maximally Ca2+-activated cardiac muscle bundles reconstituted with troponin containing either WT-cTnT (A) or cTnTS199E/T204E (B). F(t) has been normalized to initial force, F0, before step change in muscle length, L(t). Average F0 from WT-cTnT–containing muscle fiber bundles was 69.5 ± 4.0 mN/mm2; F0 from cTnTS199E/T204E-containing bundles was 40.3 ± 6.1 mN/mm2. (C) L(t) is expressed as a fraction of initial muscle length (ML). Magnitudes of step changes are ±0.5, ±1.0, ±1.5, and ±2.0% of ML.
Steven J. Ford et al. J Gen Physiol 2010;136:
© 2010 Ford et al.