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Thymidylate synthase as an oncogene?

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Presentation on theme: "Thymidylate synthase as an oncogene?"— Presentation transcript:

1 Thymidylate synthase as an oncogene?
J.R Bertino, D Banerjee  Cancer Cell  Volume 5, Issue 4, Pages (April 2004) DOI: /S (04)

2 Figure 1 The thymidylate cycle
E2F-1 as the heterodimer E2F-1/DP-1 activates transcription of TS. The other two enzymes of the thymidylate cycle are dihydrofolate reductase (DHFR) and serine hydroxymethyltransferase (SHMT). FH2, dihydrofolate; FH4, tetrahydrofolate; CH2FH4, 5-10-methylene tetrahydrofolate. Cancer Cell 2004 5, DOI: ( /S (04) )

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