1. Accumulation of β-amyloid deposits assessed by immunohistochemistry in E3FAD and E4FAD mice across dietary treatments.
Accumulation of β-amyloid deposits assessed by immunohistochemistry in E3FAD and E4FAD mice across dietary treatments. A, Representative images of β-amyloid immunoreactivity in entorhinal cortex and hippocampus in E3FAD and E4FAD males maintained on control and Western diets. Scale bar, 100 µm. β-Amyloid burden was quantified as immunoreactivity load in E3FAD and E4FAD mice in control and Western diets groups in (B) entorhinal cortex, and hippocampal subregions (C) subiculum, (D) CA1, and (E) CA2/3. Data are presented as mean (±SEM) values; n = 7–11/group. E3FAD mice are shown as circles, E4FAD mice are shown as squares; control diet groups are indicated as open symbols, and Western diet groups as filled symbols. *, p < 0.05 relative to genotype-matched mice in control diet condition. #, p < 0.05 relative to E3FAD mice in same diet condition.
V. Alexandra Moser, and Christian J. Pike eNeuro 2017;4:ENEURO
©2017 by Society for Neuroscience