1. Expected outcomes Potential problems
Research Design
Expected outcomes
Potential problems

2. Each Aim Introduction: Promise something interesting
Justification and feasibility
Review of literature
Preliminary data
Research design: what will be done
Expected outcome: return on investment
Potential problems:
Timeline
Future directions

3. Sequence for each Aim What will you do? Why does this need to be done?
What might go wrong? Should be unlikely
Alternative strategies (if hypothesis wrong)
What do you expect and why is it important?
Future directions: where will this lead?