1. aP2-Cre–mediated IKKβ deletion results in similar defects in adipose remodeling and accentuated inflammatory responses after HF feeding.
aP2-Cre–mediated IKKβ deletion results in similar defects in adipose remodeling and accentuated inflammatory responses after HF feeding. A: Western blot analysis of IKKβ protein levels in subWAT, epiWAT, liver, and macrophages of IKKβF/F and IKKβΔaP2 mice. B: Growth curves of HFD-fed male IKKβF/F and IKKβΔaP2 mice (n = 24–38). Representative photographs (C) and weight of fat pads (D) of HFD-fed male IKKβF/F and IKKβΔaP2 mice (n = 5–7). *P < E: Representative hematoxylin and eosin staining of subWAT and epiWAT of ND- or HFD-fed male IKKβF/F and IKKβΔaP2 mice. Scale bar, 100 μm. F: Representative immunohistochemistry for the macrophage marker F4/80 in subWAT and epiWAT from ND- or HFD-fed IKKβF/F and IKKβΔaP2 mice. Scale bar, 100 μm.
Se-Hyung Park et al. Diabetes 2016;65:
©2016 by American Diabetes Association