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Heaves, an asthma-like equine disease, involves airway smooth muscle remodeling  Bérénice Herszberg, DMV, David Ramos-Barbón, MD, PhD, Meiyo Tamaoka, MD,

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Presentation on theme: "Heaves, an asthma-like equine disease, involves airway smooth muscle remodeling  Bérénice Herszberg, DMV, David Ramos-Barbón, MD, PhD, Meiyo Tamaoka, MD,"— Presentation transcript:

1 Heaves, an asthma-like equine disease, involves airway smooth muscle remodeling 
Bérénice Herszberg, DMV, David Ramos-Barbón, MD, PhD, Meiyo Tamaoka, MD, James G. Martin, MD, Jean-Pierre Lavoie, DMV  Journal of Allergy and Clinical Immunology  Volume 118, Issue 2, Pages (August 2006) DOI: /j.jaci Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 ASM growth in heaves. A, Small bronchus of a horse with heaves. B, Size-matched bronchus in a control horse. C, ASM mass, heaves vs control groups. Scale bars: 250 μm. ∗P < .05. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

3 Fig 2 Immunostaining for PCNA (nuclear dark signal) colocalized with α-SMA (cytoplasmic red signal). A, High-magnification detail. B, Equivalent microscopic field in a size-matched airway of a control horse. C, PCNA+ cell numbers/mm2. Scale bars: 50 μm. ∗P < .05. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

4 Fig 3 Apoptosis detected by TUNEL and colocalized with α-SMA. The plot represents TUNEL+ cells/mm2 in heaves vs controls. ∗P < .05. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

5 Fig 4 Regression analysis of the ASM mass (A), and the numbers of PCNA+ (B) and TUNEL+ (C) ASM cells versus basement membrane length. Control horses: circles and flat (thin) linear regression functions. Heaves: triangles and thick regression curves. In heaves, the increments in ASM mass (A) and proliferating cells (B) are larger the smaller the airways. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

6 Fig 5 Regression analysis of (A) ASM mass and (B) apoptotic cells versus proliferating ASM cells/mm2. ∗Outlier. C, Summary graph of the increases in proliferating (7-fold) and apoptotic (6-fold) myocytes and ASM mass (close to 3-fold). ∗P < .05 vs control. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

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