1. Chemokines and allergic disease
Renate Nickel, MD, Lisa A. Beck, MD, Cristiana Stellato, MD, PhD, Robert P. Schleimer, PhD 
Journal of Allergy and Clinical Immunology 
Volume 104, Issue 4, Pages (October 1999)
DOI: /S (99)
Copyright © 1999 Mosby, Inc. Terms and Conditions

2. Fig. 1
Representative illustrations of chemokine subfamilies. Cysteines and disulfide bonds from which nomenclature is determined are highlighted in blue. Stalk of fractalkine (CX3C) is not drawn to scale, as indicated by parallel green lines. Transmembrane portion of fractalkine is indicated in red, and carbohydrate groups in mucin-rich stalk are indicated by magenta forms. Sequence of amino termini for structures is shown.
Journal of Allergy and Clinical Immunology  , DOI: ( /S (99) )
Copyright © 1999 Mosby, Inc. Terms and Conditions

3. Fig. 2
Hypothetic model for selective amplification of recruitment of TH1 and TH2 cells. TH1 cells may recruit more TH1 cells to tissue site by release of IFN-γ, resulting in production of IP-10 and MIG by tissue cells (left). These chemokines induce migration of CXCR3-expressing TH1 cells. An analogous mechanism is displayed for selective recruitment of TH2 cells involving IL-4 induction of MDC and TARC, which recruit CCR4 expressing TH2 cells (right). See text for references.
Journal of Allergy and Clinical Immunology  , DOI: ( /S (99) )
Copyright © 1999 Mosby, Inc. Terms and Conditions

4. Fig. 3
Chemokines trigger firm leukocyte adhesion and transendothelial migration. Activation of chemotactic 7TM receptor in context of selectin binding may trigger both inflammatory gene expression and coordinated integrin adhesion/deadhesion (see text).
Journal of Allergy and Clinical Immunology  , DOI: ( /S (99) )
Copyright © 1999 Mosby, Inc. Terms and Conditions

5. Fig. 4
Theoretical regulation of chemokine-mediated inflammation by Duffy antigen/receptor for chemokines on erythrocytes (rbc). Absence of Duffy (right) may lead to higher local concentrations of chemokines associated with endothelial presentation molecules or free in plasma (see text).
Journal of Allergy and Clinical Immunology  , DOI: ( /S (99) )
Copyright © 1999 Mosby, Inc. Terms and Conditions