1. Epigenetic Silencing Mechanisms in Budding Yeast and Fruit Fly: Different Paths, Same Destinations 
Vincenzo Pirrotta, David S. Gross 
Molecular Cell 
Volume 18, Issue 4, Pages (May 2005)
DOI: /j.molcel
Copyright © 2005 Elsevier Inc. Terms and Conditions

2. Figure 1
Mosaic Appearance of a Yeast Colony or Drosophila Eye Is Due the Metastable Chromatin State of Their Pigmentation Genes
In yeast (left), the Sir-repressed state confers red coloration; in Drosophila (right), the PcG-repressed state confers white coloration. (Yeast photograph kindly provided by Dan Gottschling.)
Molecular Cell  , DOI: ( /j.molcel )
Copyright © 2005 Elsevier Inc. Terms and Conditions

3. Figure 2
Basic Features of Sir and PcG Silencing as Suggested by Studies of Model Systems
For both mechanisms, the presence of TBP and pol II at the silenced promoter may depend on promoter context and, particularly in Drosophila, may not apply to the general case. The detailed distribution of methylation and ubiquitylation over the PcG-repressed gene is still controversial; the figure assumes that both marks are present over a broad domain.
Molecular Cell  , DOI: ( /j.molcel )
Copyright © 2005 Elsevier Inc. Terms and Conditions