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Sebastian Platelet Syndrome: A Hereditary Macrothrombocytopenia

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Presentation on theme: "Sebastian Platelet Syndrome: A Hereditary Macrothrombocytopenia"— Presentation transcript:

1 Sebastian Platelet Syndrome: A Hereditary Macrothrombocytopenia
Vilmarie Rodriguez, MD, William L. Nichols, MD, Jon E. Charlesworth, MA, James G. White, MD  Mayo Clinic Proceedings  Volume 78, Issue 11, Pages (November 2003) DOI: / Copyright © 2003 Mayo Foundation for Medical Education and Research Terms and Conditions

2 Figure 1 Case 1. Thin-sectioned blood buffy coat showing a granulocyte with nuclear lobe (N) and inclusions (arrows) that have ultrastructural features typical of classic Sebastian syndrome (uranyl acetate and lead citrate, original magnification ×17,000). The relatively structureless matrices of the inclusions contain clusters of ribosomes and a few unorganized filaments. Mayo Clinic Proceedings  , DOI: ( / ) Copyright © 2003 Mayo Foundation for Medical Education and Research Terms and Conditions

3 Figure 2 Case 2. Thin-sectioned blood buffy coat showing nucleus (N) and granulocyte inclusions (arrows) that are morphologically consistent with classic Sebastian syndrome (uranyl acetate and lead citrate, original magnification ×17,000). Mayo Clinic Proceedings  , DOI: ( / ) Copyright © 2003 Mayo Foundation for Medical Education and Research Terms and Conditions


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