1. Chromatin Modifications and Their Function
Tony Kouzarides 
Cell 
Volume 128, Issue 4, Pages (February 2007)
DOI: /j.cell
Copyright © 2007 Elsevier Inc. Terms and Conditions

2. Figure 1 Recruitment of Proteins to Histones
(A) Domains used for the recognition of methylated lysines, acetylated lysines, or phosphorylated serines. (B) Proteins found that associate preferentially with modified versions of histone H3 and histone H4.
Cell  , DOI: ( /j.cell )
Copyright © 2007 Elsevier Inc. Terms and Conditions

3. Figure 2 Crosstalk between Histone Modifications
The positive influence of one modification over another is shown by an arrow and the negative effect by a dish-line.
Cell  , DOI: ( /j.cell )
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4. Figure 3 Functional Consequences of Histone Modifications
(A) Gene-expression changes are brought about by the recruitment of the NURF complex, which contains a component BRTF recognizing H3K4me and a component-remodeling chromatin.
(B) The Crb2 protein of fission yeast is recruited to DNA-repair foci during a DNA-repair response. Crb2 is partly tethered there by association with methylated H4 and phosphorylated H2A.
(C) The HBO1 acetyltransferase is an ING5-associated factor and is therefore tethered to sites of replication via methylated H3K4. HBO1 also binds to the MCM proteins found at replication sites. Evidence exists that HBO1 augments the formation of the preinitiation complex and is required for DNA replication.
Cell  , DOI: ( /j.cell )
Copyright © 2007 Elsevier Inc. Terms and Conditions