1. Application of GABA to nucleated patches from dentate granule cells induces SR95531-sensitive channel openings.
Application of GABA to nucleated patches from dentate granule cells induces SR95531-sensitive channel openings. A, Left, Representative traces illustrating single-channel openings at consecutive stages of the experiment performed in the presence of 10 μm GABA. From top to bottom: control, SR95531 (25 μm), washout of SR Horizontal dashed lines indicate mean amplitude values of an open (O) and closed (C) state. Right, Normalized all-points amplitude histograms. B–D, Normalized average opening frequency (B), conductance (C), and open time (D) of channel openings induced by GABA application (n = 5 nucleated patches). **p < 0.01, ***p < 0.001, paired Student's t test. W/O, Washout.
Agnieszka I. Wlodarczyk et al. J. Neurosci. 2013;33:
©2013 by Society for Neuroscience