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Published byAgnes Ursler Modified over 5 years ago
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ADARs Edit MicroRNAs to Promote Leukemic Stem Cell Activity
Wen Cai Zhang, Frank J. Slack Cell Stem Cell Volume 19, Issue 2, Pages (August 2016) DOI: /j.stem Copyright © 2016 Elsevier Inc. Terms and Conditions
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Figure 1 ADAR1 Transforms Progenitors into Leukemia Stem Cells via Regulating RNA Editing Activity ADAR1 inhibition by 8-Aza limits LSCs self-renewal capacity via editing of microRNA let-7 biogenesis and the LIN28B/let-7 axis. The functional inhibition of ADAR by 8-Aza is synergistic with tyrosine kinase inhibitors (TKIs) against the JAK2 and BCR-ABL1 oncogenes. Cell Stem Cell , DOI: ( /j.stem ) Copyright © 2016 Elsevier Inc. Terms and Conditions
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