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A Synaptic Basis for GLP-1 Action in the Brain

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1 A Synaptic Basis for GLP-1 Action in the Brain
Sandrine Lefort, Matthias H. Tschöp, Cristina García-Cáceres  Neuron  Volume 96, Issue 4, Pages (November 2017) DOI: /j.neuron Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Hindbrain GLP-1 Signaling to PVN Neurons Reduces Food Intake by Regulating AMPAR Trafficking (A) Pathways connecting glucagon-like peptide-1 (GLP-1)-producing neurons in the nucleus tractus solitarius (NTSGCG) with neuronal populations from the paraventricular nucleus of the hypothalamus (PVN). CRH, corticotropin-releasing hormone; OXT, oxytocin; AVP, arginine-vasopressin. (B) Enhanced AMPAR trafficking and excitability upon GLP-1R signaling on postsynaptic PVNCRH neurons lead to a decrease in food intake. This effect is independent of presynaptic glutamate release from NTSGCG neurons. (C) Impact of genetic disruption of GLP-1R expression on postsynaptic AMPA-mediated current in PVNCRH neurons. A global, postnatal GLP-1R knockout in PVN neurons induces obesity. Neuron  , DOI: ( /j.neuron ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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