1. Volume 139, Issue 6, Pages 1877-1886.e2 (December 2010)
Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation 
Jeffrey M. Johnston, Caroline B. Kurtz, James E. MacDougall, Bernard J. Lavins, Mark G. Currie, Donald A. Fitch, Chris O'Dea, Mollie Baird, Anthony J. Lembo 
Gastroenterology 
Volume 139, Issue 6, Pages e2 (December 2010)
DOI: /j.gastro
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2. Figure 1
Weekly mean change from baseline in CSBM rate (A) and abdominal pain (B) for linaclotide 75, 150, 300, and 600 μg and placebo.
Gastroenterology  , e2DOI: ( /j.gastro )
Copyright © 2010 AGA Institute Terms and Conditions

3. Figure 2
Mean abdominal pain (A), abdominal pain in “severe” patients (B), abdominal discomfort (C), and bloating (D) ratings during the 2-week pretreatment baseline and 12-week treatment periods for linaclotide 75, 150, 300, and 600 μg and placebo.
Gastroenterology  , e2DOI: ( /j.gastro )
Copyright © 2010 AGA Institute Terms and Conditions

4. Figure 3
Percentage of patients who were (A) adequate relief responders during the 12-week treatment periods and (B) global relief responders during the 12-week treatment period for linaclotide 75, 150, 300, and 600 μg and placebo.
Gastroenterology  , e2DOI: ( /j.gastro )
Copyright © 2010 AGA Institute Terms and Conditions

5. Supplementary Figure 1 Diagram of patient flow.
Gastroenterology  , e2DOI: ( /j.gastro )
Copyright © 2010 AGA Institute Terms and Conditions