1. Age-stratified protein microarray data for different transmission settings.
Age-stratified protein microarray data for different transmission settings. (A to C) Scatter plots of the mean signal intensity for the 30 antigens with the highest antibody signal intensities (log2 FOC) by age for each transmission setting. Individual symbols represent single serum samples. Samples from RDT-negative and -positive samples are indicated by solid and open symbols, respectively. The RDT-positive samples are colored red and green to distinguish, respectively, active community surveillance samples from samples from patients with malaria presenting to rural health centers in the Macha Hospital catchment area in Choma District. (A) Choma District, Zambia, samples collected from June 2015 (n = 70 community surveillance donors, 70 samples, plus n = 35 care-seeking individuals, 35 samples). (B) Mutasa District, Zimbabwe, samples collected from April and August 2015 (n = 78 donors, 156 samples). (C) Nchelenge District, Zambia, samples collected in April, June, and August 2015 (n = 69 donors, 124 samples). Hashed lines signify children (0 to 5 years) and adults (>20 years), with the percentage of RDT-negative samples in each age group above a cutoff of a log2 FOC of >1 being shown at the top of each panel. (D) Healthy U.S. adults (n = 14). (E) Healthy adults from Papua New Guinea (n = 5). The top 30 antigens are listed in Table S1 in the supplemental material.
Tamaki Kobayashi et al. mSphere 2019; doi: /mSphereDirect