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Increased pulmonary blood flow produces endothelial cell dysfunction in neonatal swine  Eugene V Vitvitsky, MD, John P Griffin, Margaret H Collins, MD,

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Presentation on theme: "Increased pulmonary blood flow produces endothelial cell dysfunction in neonatal swine  Eugene V Vitvitsky, MD, John P Griffin, Margaret H Collins, MD,"— Presentation transcript:

1 Increased pulmonary blood flow produces endothelial cell dysfunction in neonatal swine 
Eugene V Vitvitsky, MD, John P Griffin, Margaret H Collins, MD, Thomas L Spray, MD, J.William Gaynor, MD  The Annals of Thoracic Surgery  Volume 66, Issue 4, Pages (October 1998) DOI: /S (98)

2 Fig 1 (A) Baseline pulmonary vascular resistance (PVR) in left pulmonary artery (LPA) and control animals and after acute LPA occlusion in the control (CON) animals. (B) Changes in PVR in response to inhaled nitric oxide (NO). (C) Changes in PVR after acetylcholine (ACH) infusion. Note paradoxical vasoconstriction in animals with increased pulmonary blood flow secondary to LPA ligation (WU = Wood units.) The Annals of Thoracic Surgery  , DOI: ( /S (98) )

3 Fig 2 Photomicrographs of equally distended intraacinar arteries from control (A) and left pulmonary artery ligation animals (B). The wall thickness of the two arteries are not different. The lumen of each is filled with barium/Hypaque. (×400 before 51% reduction.) The Annals of Thoracic Surgery  , DOI: ( /S (98) )

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