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Volume 4, Issue 1, Pages (February 2006)

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1 Volume 4, Issue 1, Pages 20-32 (February 2006)
Advances in Metabolic Imaging in Patients with Elevated Prostate Specific Antigen (PSA)  Michael Seitz, Bernhard Scher, Anno Graser, Oliver Reich, Christian Gratzke, Michael Scherr, Christian G. Stief, Ullrich G. Mueller-Lisse  EAU-EBU Update Series  Volume 4, Issue 1, Pages (February 2006) DOI: /j.eeus Copyright © 2005 Elsevier B.V. Terms and Conditions

2 Fig. 1 PET, CT and fused PET/CT images of a patient (63 yrs) with histopathologically proven prostate cancer in the right lobe of the prostate (arrows). 11C-choline uptake is intense. EAU-EBU Update Series 2006 4, 20-32DOI: ( /j.eeus ) Copyright © 2005 Elsevier B.V. Terms and Conditions

3 Fig. 2 11C-choline PET of a patient (73 yrs) with multiple lymph node metastases as well as multiple bone metas-tases originating from prostate cancer. EAU-EBU Update Series 2006 4, 20-32DOI: ( /j.eeus ) Copyright © 2005 Elsevier B.V. Terms and Conditions

4 Fig. 3 PET, CT and fused PET/CT images of same patient with showing a lymph node metastasis (arrows) in the right iliacal region with focal 11C-choline uptake. EAU-EBU Update Series 2006 4, 20-32DOI: ( /j.eeus ) Copyright © 2005 Elsevier B.V. Terms and Conditions

5 Fig. 4 Patient (74 yrs) with histopathologically proven prostate cancer. 11C-choline-PET upper row revealed in addition to the primary malignancy 3 bone metastases (arrows) which could be verified by 18F-flouride-PET of the skeletal system (lower row). EAU-EBU Update Series 2006 4, 20-32DOI: ( /j.eeus ) Copyright © 2005 Elsevier B.V. Terms and Conditions

6 Fig. 5 Patient (75 yrs) presenting after prostatectomy due to prostate cancer with rising PSA. 11C-choline PET revealed a local recurrence (arrows) which was later verified histopathologically. EAU-EBU Update Series 2006 4, 20-32DOI: ( /j.eeus ) Copyright © 2005 Elsevier B.V. Terms and Conditions

7 Fig. 6 Axial, T2-weighted turbo (fast) spin echo images demonstrate division of prostate into sextants (right and left base, middle gland, and apex). The base resembles the shape of a clover leaf and extends from the bladder floor to the level cranial to the axial MR image section with the largest transverse diameter of the prostate. The middle gland resembles the shape of an ellipse and extends from the level of the largest transverse diameter of the prostate to the caudal (inferior) level of the verumontanum. The apex resembles the shape of a trapezoid and extends from the next caudal level to the urogenital diaphragm. Two independent readers agreed on presence of prostate cancer in the left base, middle, and apex and absence of prostate cancer from the right base, middle, and apex. Step section histopathology confirmed MRI findings. EAU-EBU Update Series 2006 4, 20-32DOI: ( /j.eeus ) Copyright © 2005 Elsevier B.V. Terms and Conditions


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