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Fig. 5 Transcriptional changes in dKO mice after HFD regimen.

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1 Fig. 5 Transcriptional changes in dKO mice after HFD regimen.
Transcriptional changes in dKO mice after HFD regimen. (A) Volcano plot showing the significance of differentially expressed genes in iBAT of dKO versus WT in RNA-seq Diet. The total number of up-regulated (red) and down-regulated (black) genes is shown above the plot. Red dots are considered significant with an adjusted P < 0.1. (B) Network representation of functional enriched biological processes and pathways. Up-regulated genes in dKO were found enriched in several pathways (Enrichr, Fisher Test; FDR < 0.05, table S2) and grouped on the basis of the pathways they belong to. Pathways and processes were further grouped into five higher hierarchy super pathways after visually inspecting the clusters. The number of genes contained in each super pathway is shown in parentheses next to the pathway name. (C) Heatmap of normalized (Z score on samples) levels of expression of RT-qPCR–validated genes (in fig. S5) grouped by the three super clusters of interest in (B). Simona Pedrotti et al. Sci Adv 2019;5:eaav1472 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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