1. Lack of OcaB impairs age-associated B-lymphocyte accumulation in WAT
Lack of OcaB impairs age-associated B-lymphocyte accumulation in WAT. A–C: Transitional state of splenic B lymphocytes (A) and accumulation of B cells in iWAT (B) and eWAT (C) in 6-month-old OcaB+/+ and OcaB−/− mice (n = 3/group).
Lack of OcaB impairs age-associated B-lymphocyte accumulation in WAT. A–C: Transitional state of splenic B lymphocytes (A) and accumulation of B cells in iWAT (B) and eWAT (C) in 6-month-old OcaB+/+ and OcaB−/− mice (n = 3/group). D: Presence of CD19+ B cells (arrows) in iWAT (magnification ×200) and in one lymph node (magnification ×40) present within iWAT of OcaB+/+ mice. E–H: Blood levels of Igs in 6-month-old OcaB+/+ and OcaB−/− mice (n = 5/group). *P < 0.05; **P < 0.01; ***P < Foll, follicular; KO, knockout (OcaB−/−); MZ, marginal zone; N.D., none detected; NS, not significant; WT, wild type (OcaB+/+ littermates).
Sophie Carter et al. Diabetes 2018;67:
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