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Histologic features of brain vessels in patient 7 with MNGIE

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1 Histologic features of brain vessels in patient 7 with MNGIE
Histologic features of brain vessels in patient 7 with MNGIE. A, Representative image of a penetrating arteriole showing increased collagen deposition in the tunica media (arrow) (H&E, original magnification ×40). Histologic features of brain vessels in patient 7 with MNGIE. A, Representative image of a penetrating arteriole showing increased collagen deposition in the tunica media (arrow) (H&E, original magnification ×40). B, Loss of smooth-muscle cells of the tunica media in a penetrating vessel, especially evident at the outermost layer (smooth-muscle actin, original magnification ×40). C, A thick fibrous coat completely replaces the 3-layer structure of a penetrating vessel (PicroSirius Red, original magnification ×40). D, Fibrous replacement is associated with luminal narrowing in a small brain vessel (PicroSirius Red, original magnification ×40). E, Perl iron stain consistent with hemosiderin deposits close to a brain capillary (Perls stain, original magnification ×40). F, Perivascular gliosis (glial fibrillary acidic protein, original magnification ×40). L.L. Gramegna et al. AJNR Am J Neuroradiol 2018;39: ©2018 by American Society of Neuroradiology

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