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Vascular Effects of Cyclosporin A and Acute Rejection in Canine Heart Transplantation  Denis Bouchard, MD, Marc-Antoine Despatis, MD, Josie Buluran, BSc,

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Presentation on theme: "Vascular Effects of Cyclosporin A and Acute Rejection in Canine Heart Transplantation  Denis Bouchard, MD, Marc-Antoine Despatis, MD, Josie Buluran, BSc,"— Presentation transcript:

1 Vascular Effects of Cyclosporin A and Acute Rejection in Canine Heart Transplantation 
Denis Bouchard, MD, Marc-Antoine Despatis, MD, Josie Buluran, BSc, Raymond Cartier, MD  The Annals of Thoracic Surgery  Volume 64, Issue 5, Pages (November 1997) DOI: /S (97) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Light photomicrograph (Movat pentachrome) of a cross-section of the circumflex coronary artery from a transplanted heart displaying severe rejection (not treated). The right panel shows intimal hyperplasia with lymphocyte infiltration and preservation of the endothelial cells (black arrow) along with the internal lamina elastica (ILE). The upper left panel illustrates similar features with a disrupted ILE (black arrow) and lymphocyte infiltration of the underlying smooth muscle. The lower left panel depicts grade IV rejection of the myocardium with severe lymphocyte infiltration and myocyte necrosis (M). The Annals of Thoracic Surgery  , DOI: ( /S (97) ) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Immunohistologic staining for von Willebrand factor of a coronary artery segment from an acutely rejected heart showing morphologically preserved endothelial cells (upper panel: low magnification; lower panel: high magnification). The Annals of Thoracic Surgery  , DOI: ( /S (97) ) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Dose-response curve showing endothelium-dependent relaxation of coronary segments to thrombin. A significantly decreased response is observed among transplanted hearts regardless of the treatment supplied. (NaCyA = native hearts treated with cyclosporine; NA noTx = native hearts without treatment; TR CyA = transplanted hearts treated with cyclosporine; TR noTx = transplanted hearts without treatment.) The Annals of Thoracic Surgery  , DOI: ( /S (97) ) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 (A) Dose-response curve showing endothelium-dependent relaxation of coronary artery segments to 5-hydroxytryptamine (5-HT). A significantly increased response is observed among the transplanted hearts, which was enhanced further by cyclosporine treatment. (B) Dose-response curve showing an endothelium-independent response (rings without endothelium) to 5-HT. Neither the transplant process nor the cyclosporine treatment altered the response. (NA CyA = native hearts treated with cyclosporine; NA noTx = native hearts without treatment; ns = not significant; TR CyA = transplanted hearts treated with cyclosporine; TR noTx = transplanted hearts without treatment.) The Annals of Thoracic Surgery  , DOI: ( /S (97) ) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

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