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Leptin Grows Up and Gets a Neural Network

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Presentation on theme: "Leptin Grows Up and Gets a Neural Network"— Presentation transcript:

1 Leptin Grows Up and Gets a Neural Network
Roger D. Cone, Richard B. Simerly  Neuron  Volume 71, Issue 1, Pages 4-6 (July 2011) DOI: /j.neuron Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 Leptin Regulates the ARC to PVN Circuit via a Distributed Network of Predominantly GABAergic Neurons The diagram shows one example of the hundreds of POMC and NPY/AgRP projections throughout the CNS, and the network of leptin receptor expressing GABAergic neurons controlling this circuit. Major sites of leptin-responsive GABAergic neurons identified in Vong et al. include ARC, LH, and DMH. Note that most of the GABAergic and glutamatergic inputs to the POMC and NPY/AgRP neurons remain undefined. Target neurons in the PVN are highly heterogeneous and are also regulated by a complex network of GABAergic and glutamatergic inputs. Neuron  , 4-6DOI: ( /j.neuron ) Copyright © 2011 Elsevier Inc. Terms and Conditions

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