1. COPD:

38. Histological analysis of filtered air- and cigarette smoke-exposed mice. Mice were exposed for 6 mo to either filtered air or cigarette smoke. Lungs were fixed and used for morphological analyses as described in the Materials and Methods.
A, Airspace enlargement occurred in cigarette smoke-exposed mice as shown by representative H&E stained slides. Original magnification is at ×200.
B, Mucus cell metaplasia developed in cigarette smoke-exposed mice as indicated by PAS-positive cells. Positive cells are indicated by arrows. Original magnification is at ×400.
C, Macrophage accumulation occurred in cigarette smoke-exposed mice as indicated by Mac-3 staining. Mac-3 positive cells are indicated by arrows. Original magnification is at ×400.