1. Treatment response patterns and effect size over time in exclusively placebo-controlled trials.
Treatment response patterns and effect size over time in exclusively placebo-controlled trials. A: Scatter plot of HbA1c reduction in 22 placebo group treatment arms and 47 antihyperglycemic medication treatment arms plotted with year of approval. A significant meta-regression predicting placebo response (dashed line) based on year of approval was found (P = ), with an R2 of Placebo response increased by for each year following The linear meta-regression to predict antihyperglycemic response (solid line) based on year of approval was also found to be significant (P = ), with an R2 of Drug response increased by for each year following B: Scatter plot of effect sizes for 47 treatment arms plotted with year of approval. A linear meta-regression predicting effect size based on year of approval was found not to be significant (P = 0.725), with an R2 of
Arif Khan et al. Dia Care 2018;41:
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