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NF-κB Regulation by NLRs: T Cells Join the Club

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Presentation on theme: "NF-κB Regulation by NLRs: T Cells Join the Club"— Presentation transcript:

1 NF-κB Regulation by NLRs: T Cells Join the Club
Christoph A. Thaiss, Eran Elinav  Immunity  Volume 42, Issue 4, Pages (April 2015) DOI: /j.immuni Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 NLRP12 Regulates NF-κB and Cytokine Responses in T Cells
Lukens et al. (2015) demonstrate that absence of NLRP12 leads to enhanced NF-κB signaling, hyperproliferation, and elevated cytokine secretion in T cells. This results in the manifestation of auto-inflammatory disorders, including colitis, and in atypical experimental autoimmune encephalomyelitis (EAE). Immunity  , DOI: ( /j.immuni ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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