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GWAS Meets TCGA to Illuminate Mechanisms of Cancer Predisposition

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Presentation on theme: "GWAS Meets TCGA to Illuminate Mechanisms of Cancer Predisposition"— Presentation transcript:

1 GWAS Meets TCGA to Illuminate Mechanisms of Cancer Predisposition
Hyun Seok Kim, John D. Minna, Michael A. White  Cell  Volume 152, Issue 3, Pages (January 2013) DOI: /j.cell Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 Bridging the Gap between Detection of Cancer Risk Loci and Development of Disease Prevention Strategies High-resolution annotation of molecular correlates in tumor samples can be dovetailed with GWAS to elaborate causal relationships between risk loci and target genes. These target genes serve as both functional and predictive biomarkers for personalized medicine. This, in turn, can lead to testable mechanistic hypotheses and nomination of early detection and prevention strategies. Cell  , DOI: ( /j.cell ) Copyright © 2013 Elsevier Inc. Terms and Conditions

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