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Volume 54, Issue 5, Pages (June 2014)

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1 Volume 54, Issue 5, Pages 713-715 (June 2014)
Regulating Microtubules and Genome Stability via the CUL7/3M Syndrome Complex and CUL9  Peter K. Jackson  Molecular Cell  Volume 54, Issue 5, Pages (June 2014) DOI: /j.molcel Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 The 3M/Cul7 E3 Ubiquitin Ligase Complex Cooperates with the Cul9 E3 Ligase to Regulate the Cell Survival Factor Survivin and Control of Genome Stability (A) The 3M complex centers on the CUL7 E3 ubiquitin ligase, which regulates microtubule function, the CUL9 complex, and ultimately the cell survival regulator survivin. (B) Additional biochemical interactions suggest functional links to the p53 tumor suppressor, the SCF ubiquitin ligase, and the FBxW8 F-box protein, focusing future studies on the identification of additional components, biochemistry, and regulatory pathway biology. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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