1. Quiz Page Answers May 2006 American Journal of Kidney Diseases
American Journal of Kidney Diseases 
Volume 47, Issue 5, Pages e61-e63 (May 2006)
DOI: /j.ajkd
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2. Figure 51A
What do you see by light microscopy (Jones’ silver stain, original magnification ×200)?
There is mild mesangial proliferation with increased matrix, mild prominence of glomerular basement membranes, and mild to moderate afferent and efferent arteriolar hyalinosis with a capsular drop. There is also mild interstitial fibrosis. These findings are consistent with mild diabetic nephropathy. The presence of mesangial hypercellularity without Kimmelstiel-Wilson nodules suggests an early stage of the disease.
American Journal of Kidney Diseases  , e61-e63DOI: ( /j.ajkd )
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3. Figure 51B
What additional findings do you see by light microscopy (hematoxylin and eosin, original magnification ×400)?
Further examination revealed focal areas with interstitial edema and numerous eosinophils, in addition to lymphocytes and plasma cells and a vague granulomatous reaction.
American Journal of Kidney Diseases  , e61-e63DOI: ( /j.ajkd )
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4. Figure 51C
What additional findings do you see by immunofluorescence microscopy (anti-IgA antibody immunofluorescence, original magnification ×200)?
By immunofluorescence, there was 1+ mesangial staining for IgA, trace mesangial staining for C3, and very trace mesangial staining for κ and λ. Stainings for IgG, IgM, and C1q were negative.
American Journal of Kidney Diseases  , e61-e63DOI: ( /j.ajkd )
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5. Figure 51D
What do you see by electron microscopy (electron microscopy, original magnification ×5,600)?
Electron microscopy showed mild increase in thickness of the lamina densa of the glomerular basement membrane, increased mesangial matrix and cellularity, and small- to medium-size mesangial immune complex deposits (arrows).
American Journal of Kidney Diseases  , e61-e63DOI: ( /j.ajkd )
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