1. Peritoneal &pleural effusions
Maryam Mehdizadeh MD,MIAC

2. case 1: An 83-year-old man with weakness and abdominal pain since a month ago as well as acitis in clinical examination

13. What is your diagnosis?

14. High grade malignant lymphoma

15. Serous effusions are a well-recognized complication of lymphoma but rarely the detection of lymphoma cells in a serous effusion has been the first morphologic manifestation of the disease .

16. Staining methods
1.papanicolaou method 2. Air-dried Romanowsky stained preparation

17. Papanicolaou stained preparations do not
allow the same degree of correlation with
the various types of lymphoma and leuk-
emia that can be achieved by the use of
Romanowsky-stained preparations.

18. However ,not being able to type lymphoma in serous effusions is rarely a disadvantage of pap method ,because nearly all of the patients has already been diagnosed as having lymphoma .

19. Key features of lymphoma and leukemia
1. Isolated cell only 2. Cells frequently necrotic 3. Morphologic range : from seemingly mature lymphocyte to large cells with polymorphous nuclei

20. Gastric biopsy