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Volume 138, Issue 4, Pages (April 2010)

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1 Volume 138, Issue 4, Pages 1557-1565 (April 2010)
Effects of Chronic Metabolic Acidosis on Splanchnic Protein Turnover and Oxygen Consumption in Human Beings  Paolo Tessari, Antonella Sofia, Stefano Saffioti, Monica Vettore, Daniela Verzola, Renato Millioni, Lucia Puricelli, Giacomo Garibotto  Gastroenterology  Volume 138, Issue 4, Pages (April 2010) DOI: /j.gastro Copyright © 2010 AGA Institute Terms and Conditions

2 Figure 1 Leu-C kinetic balance (in μmol · min−1 · 1.73 m2 BS−1) (ie, the differences between Leu-C disposal into protein synthesis minus its release from proteolysis), across the splanchnic area, in the subjects with induced metabolic acidosis (black bars) and in controls (white bars). The kinetic data were calculated both in plasma (left bars) and in the whole blood (right bars). The P value indicates the significant difference between the acidotic and the control subjects (by the Student t test). Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

3 Figure 2 Correlation between splanchnic protein synthesis (expressed as leucine disposal into protein, in μmol · min−1 · 1.73 m2 BS−1) and splanchnic oxygen uptake (in mL · min−1 · 1.73 m2 BS−1) in all the subjects studied. The data were available from 12 subjects. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

4 Figure 3 Correlation between blood bicarbonate concentrations (in mmol/L) and splanchnic ammonia fractional extraction (expressed as %) in all the subjects studied. The data were available from 12 subjects. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions


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