1. Molecular Biology of Opioid Analgesia
Gavril W. Pasternak, MD, PhD 
Journal of Pain and Symptom Management 
Volume 29, Issue 5, Pages 2-9 (May 2005)
DOI: /j.jpainsymman
Copyright © 2005 U.S. Cancer Pain Relief Committee Terms and Conditions

2. Fig. 1
Sensitivity of CD-1 and CXBK mice to μ opioids. Mice were administered doses of the indicated drugs that were adjusted to produce a similar analgesic effect in CD-1 mice. The same doses were then given to the CXBK mice. Data from Rossi et al.15 and Pasternak.2
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3. Fig. 2
Incomplete cross-tolerance to morphine by μ opioids. Mice were administered doses of the indicated drugs that were adjusted to produce a similar analgesic effect in naïve CD-1 mice. The same doses were then given to the mice after five daily doses of morphine. Data from Rossi et al.15
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Copyright © 2005 U.S. Cancer Pain Relief Committee Terms and Conditions

4. Fig. 3
Mu opioid analgesia in an exon 1 MOR-1 knockout mouse. Morphine, morphine-6β-glucuronide (M6G) or heroin were given at the stated dosed to the wildtype or knockout mice. Data from Schuller et al.30
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5. Fig. 4
Schematic of the μ opioid receptor gene Oprm and the MOR-1 splice variants. Schematic of the structure of the Oprm gene and the identified splice variants of the mouse μ opioid receptor. Compiled from Pick et al.,17 Moskowitz and Goodman,18 and Pasternak.19
Journal of Pain and Symptom Management  , 2-9DOI: ( /j.jpainsymman )
Copyright © 2005 U.S. Cancer Pain Relief Committee Terms and Conditions