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Volume 69, Issue 11, Pages (June 2006)

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Presentation on theme: "Volume 69, Issue 11, Pages (June 2006)"— Presentation transcript:

1 Volume 69, Issue 11, Pages 2037-2042 (June 2006)
Early markers of renal dysfunction in patients with sickle cell/β-thalassemia  E. Voskaridou, E. Terpos, S. Michail, E. Hantzi, A. Anagnostopoulos, A. Margeli, D. Simirloglou, D. Loukopoulos, I. Papassotiriou  Kidney International  Volume 69, Issue 11, Pages (June 2006) DOI: /sj.ki Copyright © 2006 International Society of Nephrology Terms and Conditions

2 Figure 1 Correlation between creatinine clearance (Ccr) and Cystatin-C (Cys-C). (a) Ccr showed an inverse significant correlation with Cys-C, when patients had a Ccr of below or equal to 90 ml/min. (b) On the contrary there was no correlation between Ccr and Cys-C when patients had a Ccr of above 90 ml/min. Therefore, Cys-C measurements are useful when glomerular filtration rate (GFR) is altered only. Kidney International  , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions

3 Figure 2 Changes of proteinuria and N-acetyl-β-D-glucosaminidase (NAG) in seven patients who received angiotensin-converting enzyme (ACE) inhibitor, fosinopril 10 mg daily for 6 months. (a) Five patients reduced the degree of proteinuria by 43–76%; the other two patients showed an increase in urinary protein excretion by 8–12%. (b) The same five patients had also a reduction of NAG levels that ranged between 15 and 76%, while the two patients who experienced an increase of proteinuria showed also an increase in NAG values that ranged between 12 and 21%. Kidney International  , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions


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