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Volume 58, Issue 5, Pages (November 2000)

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Presentation on theme: "Volume 58, Issue 5, Pages (November 2000)"— Presentation transcript:

1 Volume 58, Issue 5, Pages 2129-2137 (November 2000)
Glomerular permselectivity in early stages of overt diabetic nephropathy  Steen Andersen, Kristina Blouch, Joan Bialek, Marja Deckert, Hans-Henrik Parving, Bryan D. Myers  Kidney International  Volume 58, Issue 5, Pages (November 2000) DOI: /j x Copyright © 2000 International Society of Nephrology Terms and Conditions

2 Figure 1 Design of the crossover study. Subjects were randomized to 60 days of either placebo (protocol 1) or losartan therapy (protocol 2). This was followed by a 15-day washout period after which each subject crossed over to 60 days of the remaining therapy not given on the first occasion. *Days on which differential solute clearances were performed. Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions

3 Figure 2 Sieving coefficients (θ) of Ficoll are plotted as a function of Einstein-Stokes radius (ESR). Symbols are: (○) placebo-treated diabetic nephropathy; (▵) controls; *P < 0.05. Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions

4 Figure 3 Sieving coefficients (θ) of Ficoll in diabetic nephropathy (DN) are plotted as a function of Einstein-Stokes radius (ESR). Symbols are: (○) placebo treatment; (X) losartan treatment. (Δ) P = Data are mean ± SEM. Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions


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