Presentation is loading. Please wait.

Presentation is loading. Please wait.

Lymphocytes in Peyer patches regulate clinical tolerance in a murine model of food allergy  Christophe P. Frossard, MS, Laurence Tropia, Conrad Hauser,

Published byPaula Jefferson Modified over 5 years ago

Similar presentations

Presentation on theme: "Lymphocytes in Peyer patches regulate clinical tolerance in a murine model of food allergy  Christophe P. Frossard, MS, Laurence Tropia, Conrad Hauser,"— Presentation transcript:

1 Lymphocytes in Peyer patches regulate clinical tolerance in a murine model of food allergy 
Christophe P. Frossard, MS, Laurence Tropia, Conrad Hauser, MD, Philippe A. Eigenmann, MD  Journal of Allergy and Clinical Immunology  Volume 113, Issue 5, Pages (May 2004) DOI: /j.jaci

2 Fig 1 β-Lactoglobulin–specific serum IgG1 (A), IgG2a (C), and IgE (E) antibody titers by ELISA. Numbers of BLG-specific IgG1 (B) and IgG2a (D) antibody-producing cells counted by ELISPOT in spleen or in Peyer patches. Results are pooled from at least 3 different experiences. ND, Not detectable. ∗∗P<.001, SENS (mice sensitized with β-lactoglobulin) vs CTX; ∗P<.05, TOL (mice tolerized with β-lactoglobulin) vs CTX; +P<.05, TOL vs SENS in SC; otherwise P=not significant. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

3 Fig 2 Antigen-activated MNC (A) or PPC (B) proliferation. CD3+ cells were isolated from CTX mice and activated with BLG (CTXBLG) or OVO (CTXOVO), BLG or OVO-activated cells from TOL mice (mice tolerized with β-lactoglobulin) (TOLBLG and TOLOVO), or BLG or OVO-activated cells from SENS mice (mice sensitized with β-lactoglobulin) (SENSBLG and SENSOVO). Results shown are from pooled cells in one representative experiment. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

4 Fig 3 Numbers of unstimulated and BLG-specific IFN-g (A and B), IL-4 (C and D), and IL-10 (E and F) producing cells counted by ELISPOT. Results are pooled from 3 different experiments. *P<.05, TOL (mice tolerized with β-lactoglobulin) vs SENS (mice sensitized with β-lactoglobulin); **P<.05, SENS vs CTX; +P<.05, TOL vs CTX; otherwise P=not significant. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

5 Fig 4 Naive mice (nontol) or mice previously orally tolerized to BLG (pretol) were subsequently sensitized (ip) with BLG adsorbed to alumn. BLG-specific serum IgG1 (A), IgG2a (B), and IgE (C) antibody titers from pretol and nontol mice. Antigen-activated proliferation of cells from pooled SC (D) or MNC (E). ∗P<.05, nontol vs pretol. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

6 Fig 5 β-Lactoglobulin–specific serum IgG1 antibody titers after adoptive transfer of MNC (A) or PPC (C). Numbers of IgG1 antibody-secreting cells counted by ELISPOT in SC or PP after adoptive transfer of MNC (B) or PPC (D). Results are pooled data from two different experiments. ∗P<.01, SENS (mice sensitized with β-lactoglobulin) vs TOL (mice tolerized with β-lactoglobulin); ∗∗P<.001, SENS vs TOL. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

Download ppt "Lymphocytes in Peyer patches regulate clinical tolerance in a murine model of food allergy  Christophe P. Frossard, MS, Laurence Tropia, Conrad Hauser,"

Similar presentations

Dual effects of vitamin D–induced alteration of TH1/TH2 cytokine expression  Victor Matheu, MD, Ove Bäck, MD, PhD, Emma Mondoc, BSc, Shohreh Issazadeh-Navikas,

Dual effects of vitamin D–induced alteration of TH1/TH2 cytokine expression  Victor Matheu, MD, Ove Bäck, MD, PhD, Emma Mondoc, BSc, Shohreh Issazadeh-Navikas,
Induction of systemic immunologic tolerance to β-lactoglobulin by oral administration of a whey protein hydrolysate  Rodolphe Fritsché, PhD, Jean Jacques.

Induction of systemic immunologic tolerance to β-lactoglobulin by oral administration of a whey protein hydrolysate  Rodolphe Fritsché, PhD, Jean Jacques.
Journal of Allergy and Clinical Immunology

Journal of Allergy and Clinical Immunology
Regulation of TH2 responses by the pulmonary Clara cell secretory 10-kd protein  Chih-Hsing Hung, MD, Li-Chen Chen, MD, Zhongjian Zhang, PhD, Bhabadeb.

Regulation of TH2 responses by the pulmonary Clara cell secretory 10-kd protein  Chih-Hsing Hung, MD, Li-Chen Chen, MD, Zhongjian Zhang, PhD, Bhabadeb.
High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE  Elizabeth A. Erwin,

High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE  Elizabeth A. Erwin,
IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling  Clinton B. Mathias, PhD, Suejy.

IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling  Clinton B. Mathias, PhD, Suejy.
Christophe P Frossard, MS, Conrad Hauser, MD, Philippe A Eigenmann, MD 

Christophe P Frossard, MS, Conrad Hauser, MD, Philippe A Eigenmann, MD 
The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF- like (BATF), regulates lymphocyte- and mast cell–driven immune.

The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF- like (BATF), regulates lymphocyte- and mast cell–driven immune.
The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF- like (BATF), regulates lymphocyte- and mast cell–driven immune.

The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF- like (BATF), regulates lymphocyte- and mast cell–driven immune.
Designing hypoallergenic derivatives for allergy treatment by means of in silico mutation and screening  Theresa Thalhamer, PhD, Heidi Dobias, MSc, Tatjana.

Designing hypoallergenic derivatives for allergy treatment by means of in silico mutation and screening  Theresa Thalhamer, PhD, Heidi Dobias, MSc, Tatjana.
Differential cytokine induction by the human skin–associated autoallergen thioredoxin in sensitized patients with atopic dermatitis and healthy control.

Differential cytokine induction by the human skin–associated autoallergen thioredoxin in sensitized patients with atopic dermatitis and healthy control.
Allergy prevention starts before conception: Maternofetal transfer of tolerance protects against the development of asthma  Tobias Polte, PhD, Christian.

Allergy prevention starts before conception: Maternofetal transfer of tolerance protects against the development of asthma  Tobias Polte, PhD, Christian.
Ting-ting Zhang, MSc, Klaus Okkenhaug, PhD, Baher F

Ting-ting Zhang, MSc, Klaus Okkenhaug, PhD, Baher F
Frank Kirstein, PhD, Natalie E

Frank Kirstein, PhD, Natalie E
Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis  Lisa M. Bartnikas, MD, Michael F. Gurish,

Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis  Lisa M. Bartnikas, MD, Michael F. Gurish,
Matthew C. Tunis, BSc, Wojciech Dawicki, PhD, Kaitlyn R

Matthew C. Tunis, BSc, Wojciech Dawicki, PhD, Kaitlyn R
IL-33 dysregulates regulatory T cells and impairs established immunologic tolerance in the lungs  Chien-Chang Chen, PhD, Takao Kobayashi, PhD, Koji Iijima,

IL-33 dysregulates regulatory T cells and impairs established immunologic tolerance in the lungs  Chien-Chang Chen, PhD, Takao Kobayashi, PhD, Koji Iijima,
CD1d restricted natural killer T cells are not required for allergic skin inflammation  Abdallah Elkhal, PhD, Muriel Pichavant, PhD, Rui He, PhD, Jordan.

CD1d restricted natural killer T cells are not required for allergic skin inflammation  Abdallah Elkhal, PhD, Muriel Pichavant, PhD, Rui He, PhD, Jordan.
Is 9 more than 2 also in allergic airway inflammation?

Is 9 more than 2 also in allergic airway inflammation?
A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow's milk allergy  Robert A.

A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow's milk allergy  Robert A.

Similar presentations

Ads by Google