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Ubiquinone, Idebenone, and Kinetin Provide Ineffective Photoprotection to Skin when Compared to a Topical Antioxidant Combination of Vitamins C and E with Ferulic Acid Joshua A. Tournas, Fu-Hsiung Lin, James A. Burch, M. Angelica Selim, Nancy A. Monteiro-Riviere, Jan E. Zielinski, Sheldon R. Pinnell Journal of Investigative Dermatology Volume 126, Issue 5, Pages (May 2006) DOI: /sj.jid Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 1 Prevention of erythema. (a) Erythema generated in response to UV irradiation from 1 to 5 × MED in skin treated with 1% ubiquinone solution, 1% idebenone solution, 1% idebenone cream, and 0.5% idebenone cream, and C+E+ferulic acid. Here it is evident that none of the ubiquinone or idebenone treatments offer more than one- to two-fold protection, while C+E+ferulic acid protects beyond 5 × MED. (b) Erythema generated in response to UV irradiation from 1 to 5 × MED in skin treated with 0.5% kinetin solution, 0.1% kinetin cream, and C+E+ferulic acid. Neither of the kinetin treatments offer protection, while C+E+ferulic acid protects completely at 5 × MED. Journal of Investigative Dermatology , DOI: ( /sj.jid ) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 2 Prevention of SBC generation. (a) SBCs generated in response to 1–5 × MED of UV irradiation in skin treated with antioxidant solutions. *P<0.05 versus control, **P<0.05 versus all formulations tested. (b) SBCs generated in response to 1–5 × MED of UV irradiation in skin treated with 0.5% kinetin solution, 0.1% kinetin cream, and C+E+ferulic acid. *P<0.05 vs control and kinetin formulations. Journal of Investigative Dermatology , DOI: ( /sj.jid ) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions
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