1. Frankel DS, et al. J Am Coll Cardiol. 2009;53:754-62

2. Baseline Characteristics of Study Participants by Thirds of the Adipokine Distributions*
Frankel DS, et al. J Am Coll Cardiol. 2009;53:754-62

3. Heart Failure Free Survival by Adipokine Concentration
(A and B) Kaplan-Meier curves are shown for survival free of heart failure according to baseline thirds of resistin and adiponectin (log-rank p < for resistin, p < 0.7 for adiponectin). (C and D) Dose-response relationships between resistin and adiponectin and heart failure are illustrated with generalized additive Cox models (maximally adjusted as in Model 3E) using penalized splines. Dashed lines represent 95% confidence limits of the resulting hazard ratios. (E and F) Histograms illustrate the frequency distribution of study subjects across concentrations of resistin and adiponectin. There is a linear dose-response relationship of resistin with risk of heart failure across the range where the greatest number of subjects contribute information on resistin concentration
Frankel DS, et al. J Am Coll Cardiol. 2009;53:754-62

4. Relation of Age- and Sex-Adjusted Levels of Resistin and Adiponectin to Each Other and to HOMA-IR, CRP, and BNP
Frankel DS, et al. J Am Coll Cardiol. 2009;53:754-62

5. Nested Cox Proportional Hazard Models Testing the Incidence of Heart Failure Across Adipokine Strata
Frankel DS, et al. J Am Coll Cardiol. 2009;53:754-62