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Cell-surface expression of CD25, CD26, and CD30 by allergen-specific T cells is intrinsically different in cow's milk allergy  Rogier P. Schade, MD, Adrie.

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Presentation on theme: "Cell-surface expression of CD25, CD26, and CD30 by allergen-specific T cells is intrinsically different in cow's milk allergy  Rogier P. Schade, MD, Adrie."— Presentation transcript:

1 Cell-surface expression of CD25, CD26, and CD30 by allergen-specific T cells is intrinsically different in cow's milk allergy  Rogier P. Schade, MD, Adrie G. Van Ieperen-Van Dijk, BSc, Coraline Versluis, BSc, Frank C. Van Reijsen, PhD, Jan L.L. Kimpen, MD, PhD, Carla A.F.M Bruijnzeel-Koomen, MD, PhD, Edward F. Knol, PhD, Els Van Hoffen, PhD  Journal of Allergy and Clinical Immunology  Volume 109, Issue 2, Pages (February 2002) DOI: /mai Copyright © 2002 Mosby, Inc. Terms and Conditions

2 Fig. 1 Mean of CD25-, CD26-, and CD30-expression by CMP-specific TCCs derived from infants with CMA and AD (black bars ), age-matched atopic control patients with AD but without CMA (gray bars ), and age-matched nonatopic controls (white bars ). Expression was measured as mean fluorescence intensity by using flow cytometry, 2 days after stimulation with CMPs. *P < .05 (Student t test). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

3 Fig. 2 Mean expression of CD25 (A ), CD26 (B ), and CD30 (C ) by CMP-specific TCCs derived from infants with CMA and AD, before and after the development of tolerance, and age-matched atopic control patients with AD without CMA at both time points. Nonatopic control infants from the first time point are shown as reference. Expression was measured as mean fluorescence intensity by using flow cytometry, 2 days after stimulation with CMPs. T1, First time point (before tolerance); T2, Second time point (after tolerance). *P < .05 (Student t test). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

4 Fig. 3 Correlations between expression of CD25 and CD30 (A ) and between expression of CD26 and CD30 (B ) by the CMP-specific TCCs investigated in this study. Expression was measured as mean fluorescence intensity by using flow cytometry, 2 days after stimulation with CMPs. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

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