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Differences in antigen-specific T-cell responses between infants with atopic dermatitis with and without cow’s milk allergy: Relevance of TH2 cytokines 

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Presentation on theme: "Differences in antigen-specific T-cell responses between infants with atopic dermatitis with and without cow’s milk allergy: Relevance of TH2 cytokines "— Presentation transcript:

1 Differences in antigen-specific T-cell responses between infants with atopic dermatitis with and without cow’s milk allergy: Relevance of TH2 cytokines  Rogier P. Schade, MD, Adrie G. Van Ieperen-Van Dijk, BSc, Frank C. Van Reijsen, PhD, Coraline Versluis, BSc, Jan L.L. Kimpen, MD, PhD, Edward F. Knol, PhD, Carla A.F.M. Bruijnzeel-Koomen, MD, PhD, Els Van Hoffen, PhD  Journal of Allergy and Clinical Immunology  Volume 106, Issue 6, Pages (December 2000) DOI: /mai Copyright © 2000 Mosby, Inc. Terms and Conditions

2 Fig. 1 Proliferative responses of PBMCs from 12 infants with atopic dermatitis, 6 with CMA and 6 without CMA (non-CMA) , to the 3 major cow’s milk allergens. [3H]-TdR incorporation was measured 6 days after stimulation with the allergens. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2000 Mosby, Inc. Terms and Conditions

3 Fig. 2 Antigen-specific production of IL-4 and IFN-γ by cow’s milk–specific TCCs established from infants with AD with CMA (A) and without CMA (B) . Cytokine production was measured in culture supernatants 24 hours after stimulation with irradiated, autologous, EBV-transformed B cells preincubated overnight with CMPs. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2000 Mosby, Inc. Terms and Conditions

4 Fig. 3 Correlation between antigen-specific production of IL-4 and IL-5 (A) and IL-4 and IL-13 (B) by cow’s milk–specific TCCs established from infants with AD with and without CMA. Filled circles represent clones from allergic infants, and open circles represent clones from nonallergic infants. Cytokine production was measured in culture supernatants 24 hours after stimulation with irradiated, autologous, EBV-transformed B cells preincubated overnight with CMPs. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2000 Mosby, Inc. Terms and Conditions

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