1. Nicotine and amphetamine modify burst and pause activity.
Nicotine and amphetamine modify burst and pause activity. A, Nicotine blocked the reduction of discrete burst activity by amphetamine in ChIs from saline-treated mice. For all panels, *p<0.05, **p<0.01, paired t test. B, The burstiness of ChIs from saline-treated mice was unaffected by amphetamine or the coadministration of nicotine. C, Amphetamine with nicotine or without did not change discrete pausing or (D) pause strings in ChIs from saline-treated mice. E, In ChIs from amphetamine self-administering mice, amphetamine or coadministered nicotine did not modify discrete bursting (F) but nicotine increased the length of bursting. G, Nicotine blocked the increase in discrete pausing by amphetamine in ChIs from amphetamine self-administering mice. H, In ChIs from amphetamine self-administering mice, an amphetamine challenge produced a nicotine-dependent enhancement of pause strings by boosting the intra-pause frequency and the percentage of time spent pausing.
Granville P. Storey et al. eneuro 2016;3:ENEURO
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