1. Long-Term Quantitative Analysis of Posterior Capsule Opacification After Implantation of Dual-Optic Accommodating IOLs
Andrea Galvis, MD 1 , 3
Ivan Ossma Gomez,MD MPH 1 , 2
1 Fundación Valle del Lili Cali, Colombia
2 Universidad Industrial de Santander Bucaramanga, Colombia
3 Fundación Oftalmológica de Santander Bucaramanga, Colombia
Authors are clinical investigators for the Synchrony Dual Optic Accommodating IOL

2. Synchrony Dual Optic Accommodating IOL
Fills the capsular bag
Designed to provide accommodation via forward movement of the anterior optic
Potential for movement could be impaired by capsule opacification
ACO
PCO
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3. Clinical Experience Synchrony
Good unaided distance, intermediate and near visual function 1,2,3
Subjective and objective evidence of accommodative amplitude 4,5,6
Stability of over 2 years 1,2
Low PCO rates 7
Functional range of vision exceeding that of multifocals 8
Over the past 5 years, several authors including myself have shown that the Synchrony Accommodating IOL yileds good unaided visual function at all ranges, with objective evidence of accommodation and stability throughout time. Additionally the lens has very low rates of capsule opacification.
1 Alarcon et al. ESCRS London 2006
2 Ossma et al. ASCRS San Francisco 2006
3 Beiko G. ESCRS London 2006
4 Ossma et al. ASCRS San Diego 2004
5 Galvis et al. ASCRS Washington 2005
6 Bohorquez et al. ESCRS London 2006
7 Galvis et al. ESCRS Berlin 2008
8 Ossma et al. ASCRS Chicago 2008
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4. Rabbit Studies* *Werner et al. JCRS 2004; 1114-23 Synchrony
Plate Haptic IOL
Difference in PCO
Synchrony ± 0.751
Plate haptic IOL ± 0.899
*Werner et al. JCRS 2004;
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5. Study Design Prospective Observational Analytical Study 3 Groups
Synchrony IOL Implantation (43 eyes)
Alcon SN60D3 (42 eyes)
Alcon SN60AT Implantation (54 eyes)
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6. Study Design
Digital retroillumination photographs (3,6,12 and 24 months)
Evaluate incidence PCO
OSCA System
Evaluate incidence ACO
Photography grading one observer
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7. OSCA (Open Access Systematic Capsule Assessment)
Aslam et al. ¹-²-³
Based on texture analysis
Objective
Valid
Reliable
¹ Aslam et al. BMC Ophthalmology 2005, 5:9
² Aslam et al. BMC Ophthalmology 2006, 6:30
³ Paton et al. BJO 2002, 86:
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8. * Kruskal Wallis Analysis of Variance
Study Population
Synchrony
(n=43)
SN60D3
(n=42)
SN60AT
(n=54) *
Age
68.8 ± 5.4
68.5 ± 5.4
70.1 ± 5.6
p=0.55
Residual Refraction
Defocus Equivalent
0.32 ± 0.153
0.22 ± 0.184
0.20 ± 0.157
p=0.48
* Kruskal Wallis Analysis of Variance
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9. Results Alcon SN6AD3 21.3 months postop Synchrony 20.7 months postop
Alcon SN60AT
21.1 months postop
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10. CLINICALLY SIGNIFICANT PCO
OSCA Score Evolution
CLINICALLY SIGNIFICANT PCO
p=0.41
p=0.83
OSCA Score
p=0.27
p=0.38
Mann-Whitney Test
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11. Anterior Capsule Opacification Month 12
Synchrony
n=43
SN60D3
n=42
SN60AT
n=54
None - Mild 40
(93.1%) 35
(83.3%) 47
(87%)
Moderate 3
(6.9%) 7
(16.7%) 6
(11.1%)
Severe 1
(1.9%)
Fisher’s Exact Test p=0.37
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12. Conclusion
Elements in design of Synchrony Dual Optic Accommodating Intraocular Lens
Minimize ACO
Minimize PCO
Synchrony Dual Optic Accommodating IOL
PCO Rates comparable to those of acrylic monofocal and multifocal IOLs
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13. Thank you