1. Decreased M1 and increased M2 macrophages in eWAT and liver of DIO mice due to linagliptin administration.
Decreased M1 and increased M2 macrophages in eWAT and liver of DIO mice due to linagliptin administration. A and B: FACS analysis of the stromal vascular cells of epididymal fat pads of mice fed the NC, HF, HF+Lina, or HF+Sita diet for 14 weeks. A: Representative plot of total macrophages (top) and expression of M1 and M2 macrophages (bottom) of mice. B: Quantification of ATMs, M1 ATMs, and M2 ATMs. Data are total ATM counts, percentages of M1 ATMs, percentages of M2 ATMs, and M1/M2 ratios. C and D: FACS analysis of the hepatic nonparenchymal cell fractions. C: Representative plot of total macrophages (top) and expression of M1 and M2 LMs (bottom). D: Quantification of total macrophage counts, percentages of M1 LMs, percentages of M2 LMs, and M1/M2 ratios. n = 6–8. *P < 0.05, **P < 0.01 vs. NC group; †P < 0.05, ††P < 0.01 vs. HF group; ‡P < 0.05 vs. HF+Lina group.
Fen Zhuge et al. Diabetes 2016;65:
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