1. miR-133a mimic treatment improves contractility of the diabetic heart.
miR-133a mimic treatment improves contractility of the diabetic heart. A: Pressure and dP/dt data on control (Sham), scrambled miRNA–treated diabetic (DM+scm), and miR-133a mimic–treated diabetic (DM+miR) rats. A (i): Representative LV pressure recordings of hearts from three groups. A (ii): Bar graph shows the mean values of LV pressure with SEM. B (i): Representative recordings of rates of LV pressure changes over time (±dP/dt) in hearts from the three groups at the basal level and after treatment with 0.1 µg/kg isoproterenol (a β-AR agonist). B (ii): Bar graph shows the mean ± SEM value of dP/dt in the three groups at the basal level and with two increasing doses of isoproterenol (control/sham: n = 5, DM+scm: n = 6, and DM+miR-133a: n = 5).
Shyam Sundar Nandi et al. Diabetes 2016;65:
©2016 by American Diabetes Association