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Childhood epidermolysis bullosa acquisita with autoantibodies against all 3 structural domains of type VII collagen  Takaya Fukumoto, MD, Toshiki Umekawa,

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Presentation on theme: "Childhood epidermolysis bullosa acquisita with autoantibodies against all 3 structural domains of type VII collagen  Takaya Fukumoto, MD, Toshiki Umekawa,"— Presentation transcript:

1 Childhood epidermolysis bullosa acquisita with autoantibodies against all 3 structural domains of type VII collagen  Takaya Fukumoto, MD, Toshiki Umekawa, MD, Masanori Higuchi, MD, Takashi Hashimoto, MD, Hauke Shumann, MD, Leena Bruckner- Tuderman, MD, Hideo Asada, MD, Sachiko Miyagawa, MD  Journal of the American Academy of Dermatology  Volume 50, Issue 3, Pages (March 2004) DOI: /S (03)

2 Fig 1 Erythematous macules with blisters on lower leg.
Journal of the American Academy of Dermatology  , DOI: ( /S (03) )

3 Fig 2 a, Western immunoblot analysis of normal human dermal extracts. Arrowhead indicates 290-kd epidermolysis bullosa acquisita (EBA) antigen. Control EBA serum (lane 1) and patient's serum (lane 2) reacted with EBA antigen, whereas normal control serum (lane 3) showed no reactivity. b, Immunoblot of recombinant fusion proteins of type VII collagen domains NC1 and NC2. Arrowheads indicate respective positions of fusion proteins. Both control EBA serum (lane 1) and patient's serum (lane 2) reacted with NC1 and faintly with NC2, whereas normal serum (lane 3) did not recognize either of fusion proteins. c, Immunoblot analysis of pepsin-treated keratinocyte extract revealed weak reactivity of patient's serum with triple-helical domain of type VII collagen (lane 1, upper arrow) and P1 fragment (lane 1, lower arrow). Control antibody (rabbit) to triple-helical domain is shown in lane 2. Journal of the American Academy of Dermatology  , DOI: ( /S (03) )

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