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Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity  Abena S. Amoah, MSc, Benedicta.

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Presentation on theme: "Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity  Abena S. Amoah, MSc, Benedicta."— Presentation transcript:

1 Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity  Abena S. Amoah, MSc, Benedicta B. Obeng, BSc, Irene A. Larbi, MSc, Serge A. Versteeg, BSc, Yvonne Aryeetey, BSc, Jaap H. Akkerdaas, PhD, Laurian Zuidmeer, PhD, Jonas Lidholm, PhD, Montserrat Fernández-Rivas, MD, PhD, Franca C. Hartgers, PhD, Daniel A. Boakye, PhD, Ronald van Ree, PhD, Maria Yazdanbakhsh, PhD  Journal of Allergy and Clinical Immunology  Volume 132, Issue 3, Pages (September 2013) DOI: /j.jaci Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Overlap between reported adverse reactions to peanut and peanut sensitization (IgE levels and SPT responses) for subjects with complete data for allergy-related parameters (n = 1004). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 A, Measurement of specific IgE levels to whole peanut extract, recombinant peanut allergens, profilin, and the CCD marker bromelain in a subset (n = 43). Median specific IgE levels are indicated by black lines. The dotted line shows an IgE sensitization cutoff of 0.35 kU/L. B, Correlation between peanut-specific IgE and CCD-specific IgE levels. Open circles indicate subjects with IgE to rAra h 9 of greater than 1.5 kU/L. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Inhibition of IgE binding to whole peanut by bromelain and S haematobium SEA by using pooled sera (n = 17). The figure shows that IgE binding to whole peanut extract was almost completely inhibited by bromelain (diamonds) and S haematobium SEA (triangles), respectively. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 BHR assay results. BHR induced by peanut extract (solid circles), S haematobium SEA (open triangles), and Ara h 9 (open circles). A and B, Results for 2 subjects with high IgE titers against peanut and CCD. C and D, Results for 2 subjects with high IgE titers against peanut and Ara h 9 but low IgE titers against CCDs. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E1 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig E2 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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