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Human basophils may not undergo modulation by DC-SIGN and mannose receptor– targeting immunotherapies due to absence of receptors  Mrinmoy Das, MSc, Caroline.

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Presentation on theme: "Human basophils may not undergo modulation by DC-SIGN and mannose receptor– targeting immunotherapies due to absence of receptors  Mrinmoy Das, MSc, Caroline."— Presentation transcript:

1 Human basophils may not undergo modulation by DC-SIGN and mannose receptor– targeting immunotherapies due to absence of receptors  Mrinmoy Das, MSc, Caroline Galeotti, MD, Emmanuel Stephen-Victor, MSc, Anupama Karnam, MSc, PhD, Srini V. Kaveri, DVM, PhD, Jagadeesh Bayry, DVM, PhD  Journal of Allergy and Clinical Immunology  Volume 139, Issue 4, Pages e1 (April 2017) DOI: /j.jaci Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Human basophils are deficient for DC-SIGN and CD206. A-C, Flow cytomeric analysis of DC-SIGN and CD206 on steady-state basophils, stimulated basophils (IL-3 or IL-3 and anti-IgE), and monocytes and monocyte-derived DCs. Representative dot-plots and percentage of cells (mean ± SEM, n = 3) positive for DC-SIGN and CD206. ***P < .001. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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